Saint Louis · US

Hampton Inn & Suites St. Louis/South I-55

Name: Hampton Inn & Suites St. Louis/South I-55
Address: 4200 Midamerica Lane, St. Louis, Missouri, 63129, Saint Louis, 63129
Telephone: +1 314-894-1900
Rating: 10

Exceptional154 reviews

Free WiFiWheelchair accessible parkingFree self parkingWheelchair-accessible van parkingWheelchair-accessible poolConference space

Check-in / Check-out

From 03:00 PM · Until 11:00 AM

Classification

2-Star Hotel

Amenities

Elevator, Fitness facilities, ATM/banking, Conference space, Fireplace in lobby, Television in common areas

Location

Saint Louis, US

Recreational Amenities and Features

Indulge in relaxation at the indoor pool or maintain your fitness routine in the on-site fitness center. Unwind by the cozy fireplace in the lobby or grab a snack from the convenient vending machine.

Complimentary Services and Offerings

Stay connected with free wireless internet access, enjoy a daily buffet breakfast, and make use of complimentary wired internet access. Benefit from amenities such as a business center, express check-in, and free self-parking.

Accommodations and Nearby Attractions

Retreat to one of the 92 guestrooms equipped with modern amenities. Explore nearby landmarks like Barnes Jewish South Campus and Suson Park, with various other attractions just a short drive away.

For a convenient and comfortable stay in St. Louis, book your stay at Hampton Inn & Suites St. Louis/South I-55 today!

Loading rooms and rates...

Location

How to Find Us

4200 Midamerica Lane, St. Louis, Missouri, 63129

Saint Louis · US

+1 314-894-1900

Policies

Good to Know

Check-in & Check-out

Check-in from 03:00 PM. Check-out by 11:00 AM. Early check-in and late checkout may be available upon request.

Cancellation

Cancellation terms vary by rate. Flexible rates allow free cancellation up to 24–48 hours before arrival. Non-refundable rates cannot be canceled or modified.

Payment

Prices include the taxes and fees paid when you book. Some hotels charge a resort, city or service fee on arrival; where they do, the amount is shown with each room and at checkout. A valid credit card is required at check-in.

Important Information

Pool access available from 8 AM to 10 PM.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Contactless check-in and contactless check-out are available.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
A deposit may be required at the property.

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Saint Louis · US

Hampton Inn & Suites St. Louis/South I-55

Exceptional154 reviews

Free WiFiWheelchair accessible parkingFree self parkingWheelchair-accessible van parkingWheelchair-accessible poolConference space

Check-in / Check-out

From 03:00 PM · Until 11:00 AM

Classification

2-Star Hotel

Amenities

Elevator, Fitness facilities, ATM/banking, Conference space, Fireplace in lobby, Television in common areas

Location

Saint Louis, US

Recreational Amenities and Features

Indulge in relaxation at the indoor pool or maintain your fitness routine in the on-site fitness center. Unwind by the cozy fireplace in the lobby or grab a snack from the convenient vending machine.

Complimentary Services and Offerings

Accommodations and Nearby Attractions

Retreat to one of the 92 guestrooms equipped with modern amenities. Explore nearby landmarks like Barnes Jewish South Campus and Suson Park, with various other attractions just a short drive away.

For a convenient and comfortable stay in St. Louis, book your stay at Hampton Inn & Suites St. Louis/South I-55 today!

Loading rooms and rates...

Guest Reviews

What Guests Say

10.0

Exceptional

154 reviews

Highlights

+Cleanliness
+Helpful staff
+Great location
+Modern rooms
+Good breakfast options

Could Improve

–Racial incident mentioned
–Confusion with towel service
–Security staff behavior

Cleanliness10.0

Many reviews mention cleanliness and well-maintained facilities.

Service10.0

Multiple reviewers highlighted the helpfulness and caring nature of the staff.

Location10.0

Location is praised for being convenient, especially for visiting friends.

Room Quality10.0

Room quality is consistently mentioned as clean and modern.

Amenities10.0

Amenities like the pool area and breakfast options received positive mentions.

Value for Money10.0

Guests feel that the quality of service and amenities justifies the cost.

Food and Beverage10.0

Praises for breakfast offerings, particularly the scones.

Overall Experience10.0

Reviewers express overall satisfaction and willingness to return.

Yanna513

Family · Mar 2026

Stranger than fiction

Liked:TRAVELER BEWARE I’ve stayed at many HILTON properties over the years and have generally had positive experiences, so what happened during this stay was not only shocking but deeply unsettling. Within minutes of checking in, we received a call from the front desk asking us to come down to the lobby due to a tornado warning. We complied without question because that sounds serious. When we got downstairs, only a handful of guests were there — not the entire hotel. No announcements, no urgency, nothing that resembled an actual emergency protocol. That should have been our first red flag. The next morning we received a second call from the same front desk employee asking me to vacate our room so that pest control could come in and treat it. I said No, I’m working and I don’t want a room filled with chemicals! She said, “okay, we will do it another day” At that point something felt very wrong. I went down to the front desk and questioned her directly and she actually admitted, that the pest control story was completely fabricated. Her exact words were that she just wanted to see if we were in the room. I asked her “what is it to you whether we’re in the room? It’s paid for”. She shrugged and said “I don’t know.” No explanation. No apology. Just a shrug. The whole thing didn’t feel right, it didn’t feel safe so we left. We reported the incident to the front desk manager and contacted Hampton Inn corporate headquarters. The hotel refunded our unused nights without dispute and apologized. A formal corporate complaint is on file. It was the oddest thing and it makes you wonder how often staff may target guests and then call the room phone to see if the coast is clear.

via tripadvisor

walletbuffer

Couples · Feb 2026

Would stay here again on our way back home

Liked:Very nice hotel with a very good breakfast. Room was very clean and the beds were very comfortable.

via tripadvisor

jeanmJ2034CQ

Friends Getaway · Oct 2025

Very lovely place

Liked:Lovely property, clean, well maintained. The breakfast lady Kathi is such a delight and love the breakfast scones. This hotel was located near our friends house....I would definitely recommend this hotel.

via tripadvisor

benniec571

Couples · Sep 2025

Racial Incident

Liked:We stayed at the Hampton Inn, 4200 Midamerica Lane, I55 South, in St Louis, MO. on September 1, 2025. Honestly, we feel we had a strange encounter with the older lady checking us in at the front counter. First, the lady gave us a strange look as we walked in and her eyes kept looking at me and my lady friend who just happened to be white. I am African-American. Don’t know what that was all about, but she kept this serious look on her face and absolutely had no smiles for us. Hey, maybe she was having a bad day. But, after taking my credit card and checking my drivers license (extremely slow and closely), she then proceeded to asked me to write down the full description of the vehicle we arrived in. She specifically said, (as she look out the window at our car), give me a description of the car you came in outside. She requested the make, model, color of the car and any other description of the car. Honestly, this made me feel somewhat uncomfortable because this had never happened to me before at a Hilton property. And, I am a diamond's honors member. I’ve stayed at many Hampton Inn over the years. I would like to mention, there were no section on the check-in form that asked specifically for car descriptions and details so I had to write it in on the form. Does anyone know if this is a new policy or was this a racial discriminatory incident. Honestly , I just don’t know what happened.

via tripadvisor

Location

How to Find Us

4200 Midamerica Lane, St. Louis, Missouri, 63129

Saint Louis · US

+1 314-894-1900

Policies

Good to Know

Check-in & Check-out

Check-in from 03:00 PM. Check-out by 11:00 AM. Early check-in and late checkout may be available upon request.

Cancellation

Cancellation terms vary by rate. Flexible rates allow free cancellation up to 24–48 hours before arrival. Non-refundable rates cannot be canceled or modified.

Payment

Important Information

Pool access available from 8 AM to 10 PM.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Contactless check-in and contactless check-out are available.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
A deposit may be required at the property.

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